Scientist in High-Content Screening (CRISPRa/i, ORF)

Redwood City, CA
Science /
Full-time /
Retro Biosciences is a fast-growing biopharma startup using high-throughput, high-dimensional approaches to develop therapies for diseases driven by the biology of aging. We are looking to expand our exceptional team at our Redwood City location. 

We are looking for a highly organized and self-motivated Scientist in High-Content Screenings who craves a challenge and feels energized to roll up their sleeves. Apply if you are a well-organized, creative, and technically capable scientist comfortable implementing methods in the same year they are first published. This position is ideal for an individual who is entrepreneurial and eager to learn and grow exponentially within a collaborative and supportive team of fellow scientists and engineers.  

In this role, you will:

    • Develop strategies for and establish high-content assays
    • Collaborate with Retro’s lab automation, reprogramming and computational teams
    • Implement in vivo and in vitro CRISPRa/i, ORF assays with sequencing readout
    • Analyze and present experimental data to internal teams and collaborators
    • Perform, analyze and interpret pooled and arrayed genome perturbations (knockout, knockdown, and over-expression) screens to support discovery projects

Primary qualifications:

    • Ph.D. or equivalent 3-8 years of intensive, relevant research experience
    • Industry experience is a plus
    • Experience with generating and analyzing next-generation sequencing data
    • Proven track record of developing and executing novel high-throughput, high-content and/or pooled assays in mammalian cells
    • Experience with single-cell, high-throughput assays
    • Cell biology expertise including cell culture, viral transduction, transfection
    • Molecular biology experience including construct design and DNA cloning
    • Excellent interpersonal skills and ability to work efficiently and productively in a dynamic, scientifically rigorous, and fast-paced environment
    • Knowledge of immunology is a plus

You may be a good match for this role if:

    • You enjoy supporting and empowering others
    • You can balance multiple competing priorities and resolve problems
    • You embrace the process of adapting to new and changing situations and can adjust as needed
    • You are happy to jump in and help with any task that comes your way 
    • You are adaptable, responsive, and high energy
    • Detail-oriented, organized, and technically competent
    • You are enthusiastic about rapidly and creatively experimenting, learning, and improving
    • You are excellent at explaining technical concepts clearly
    • You have excellent interpersonal skills and have an open communication style
Our mission is to extend healthy human lifespan by one decade.

Retro develops therapies for diseases driven by the biology of aging. We work on (1) partial reprogramming, (2) blood factors, and (3) autophagy to rejuvenate cell and tissue function with the ultimate aim of adding years to healthy human lifespan.  We are looking to expand our exceptional team at our Redwood City location. The annual salary range for this role is $140,000 - $160,000. Total compensation also includes generous equity and benefits. Benefits and perks:

- Medical, dental, and vision insurance for you and your family
- 401(k) plan with 4% matching
- Unlimited time off and 10 company holidays per year
- Paid parental leave 
- Annual learning & development stipend 
- Free lunch and snacks