Vice President, Translational Sciences & Precision Medicine

Cambridge, MA /
R & D /
The Company
Rheos Medicines is a precision medicine company using insights from immunometabolism to bring novel therapeutics to patients suffering from autoimmune diseases. The company’s approach elucidates the underlying complexities and heterogeneity of immune mediated disease via a proprietary platform and product engine that integrates multiple “-omic” datasets through a metabolic lens. Rheos systematically defines the biologic links between immune cell metabolism and function across patient subsets and advances novel biomarker-enabled small molecule therapeutics to bring precision to the treatment of immune-mediated diseases. In December 2019, we entered a worldwide collaboration with Roche to identify and develop new therapeutics for autoimmune and inflammatory disease. Rheos was founded by Third Rock Ventures and is located in Cambridge, MA

The Role
The Head of Translational Sciences and Precision Medicine will work strategically across Research and Development in close partnership with project teams and external partners from target identification through clinical development. This role is the pivotal bridge between Research, Clinical Development and Patients. The main objective for this role will be to implement Rheos’s metabolic precision medicine approach to increase success rate of POC clinical trials, and advance transformative therapies in areas of unmet medical need in immune-mediated diseases.

·         Contribute to the culture, vision, strategy, and goals of Rheos as a Member of the Company's Research and Development Leadership team
·         Develop the Precision Medicine strategy with the goal of identifying metabolic mechanistic drivers of disease that can guide target identification, indication selection, and identify patients most likely to benefit from therapeutic intervention.
·         Define a translational path for portfolio programs to drive novel biomarker discovery and validation and enable learning and decision making in early clinical development.
·         Collaborate with various research and development colleagues within Rheos and partnered alliances to drive success of project team goals.
·         Lead procurement of patient samples including Phase 0/observational studies to enable Rheos’ overall precision medicine strategic goals
·         Manage and maintain strategic collaboration with Patients Like Me registry
·         Identify KOLs and clinical experts and lead consultations (individually and via SABs) to define precision medicine approach, translation plan, and preclinical package to support Rheos programs at IND and clinical development. 
·         Facilitate external interactions with medical disease experts, global regulatory agencies, patient advocacy organizations, research foundations, and academic innovators.
·         Author, edit, review and approve study reports and regulatory submissions from Pre-IND submission through early phase clinical trials.
Requirements & Qualifications
·         MD/PhD or PhD in life sciences or medical sciences, and a minimum of 10+ years of biotechnology or pharmaceutical industry experience, with 5+ years in clinical development; experience in immune-mediated disease areas is preferred.
·         Experience in supporting INDs, NDAs and developing Companion Diagnostics.
·         In-depth knowledge of implementing pharmacodynamic and target-engagement biomarker strategies in clinical drug development.
·         Experience in the application of various biomarker technologies as well as various high dimensional exploratory platforms (eg. transcriptomic, proteomic, metabolomics).
·         Experience in clinical protocol design, clinical trial operations, clinical trial biospecimen logistics, analytical and clinical validation of biomarker assays, and/or vendor interactions is desirable.
·         Must have deep knowledge of Immunology and Immune-mediated disease. Demonstrated knowledge of immunometabolism is desirable.  
·         Strong collaborative skills that cross the scientific disciplines involved in both R&D
·         Capable of managing and influencing external collaborations with a global network of scientific, clinical, and translational advisors.
·         Demonstrated experience and success in the planning, control and monitoring of complex and highly visible drug development projects and activities in pharmacology and translational medicine.
·         Proven scientific/leadership expertise
·         Demonstrated scientific and leadership skills and the ability to influence senior leaders and stakeholders and lead complex partnership and alliance activities.
Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.