Associate Engineer, Upstream/Downstream Process Development

Cambridge, MA /
Technical Operations & Manufacturing /
Rubius Therapeutics is a clinical-stage biopharmaceutical company developing a new class of medicines called Red Cell Therapeutics™. Our proprietary RED PLATFORM® was designed to genetically engineer and culture Red Cell Therapeutics™ that are selective, potent and off-the-shelf allogeneic cellular therapies for the potential treatment of several diseases across multiple therapeutic areas. Our therapies can potentially be used to kill tumors in cancer and to regulate the immune system for the treatment of autoimmune diseases. We are currently enrolling patients in a Phase 1/2 clinical trial of RTX-240, an allogeneic cellular therapy for the treatment of patients with relapsed/refractory or locally advanced solid tumors. Additionally, we plan to file an IND for RTX-321 for the treatment of HPV-positive tumors by year-end.

We are proud of our passionate, high-performance culture – one based on a set of values that are the cornerstone of who we are and how we hold ourselves accountable. Founded in 2013, we are based in Cambridge, MA and currently expanding across all functions within the organization. Red blood cells are no longer just for carrying oxygen. Check us out at, or follow us on Twitter and LinkedIn or like us on Facebook.

We are seeking an Associate Engineer in the Cell Product Development group, focused on upstream and downstream of bioprocessing for the cellular therapy. They will work directly with a team of scientists to optimize, scale-up, and characterize the novel cell therapy platform to increase productivity and/or advance the clinical pipeline. They will be involved in hands-on manipulation of ex vivo derived cells, and collection and logging of a variety of generated data sets.  The right candidate will have experience in laboratory research either in industry or academic settings.


    • Directly involved in the upstream and downstream process development lab activities at small scale
    • May be involved in pilot scale operations for upstream and downstream process development
    • Maintain cells in culture including routine media additions, harvest, and sampling and perform assays related to in-process controls and product release.
    • Performs routine analytics as part of process development experimentation
    • Manage material inventory and prepare solutions in support of both upstream and downstream lab activities.
    • Oversee scheduling of routine maintenance, calibration, and decontamination of the cell culturing equipment.
    • Document data and results in electronic lab notebook and related database.

Qualifications & Education

    • BS in Life Sciences or Engineering with 0 - 2 years of relevant laboratory experience.
    • Excellent bench skills with attention to details and high standards for data integrity and quality.
    • Experience with aseptic and mammalian cell culturing techniques is desirable.
    • Prior industrial experience in gene and/or cell therapy process development and/or experience with stem cells in an academic setting with industrial biologics process development is a plus.
    • Prior experience with bioreactors, centrifugation, depth filtration, and flow cytometry are a plus
    • Proficiency with MS Office programs including Outlook, Excel, and PowerPoint
    • Team-oriented with excellent communication and collaboration skills.
    • This role is lab based in our Cambridge office.
EEO Statement: Rubius Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & staffing agencies: Rubius Therapeutics does not accept agency resumes unless contacted directly by internal Rubius Talent Acquisition. Please do not forward resumes to our account, Rubius employees or any other company location; Rubius Therapeutics is not responsible for any fees related to unsolicited resumes.