Scismic is supporting the growth of a biotech company that is developing organ-on-a-chip technology. We are seeking a highly motivated Cell Biologist (Assistant Scientist/Associate Scientist/Scientist) to join the team.

- Design and execute laboratory experiments and analyze data for ongoing projects utilizing long-term tissue culture of primary cells and/or iPSCs in 2D and 3D formats and measuring quantitative, physiologically relevant readouts.

- Use cell biology and tissue engineering approaches to develop modern pharmacology tools for preclinical DMPK studies including human-relevant microphysiological systems, tissue chips, organ-on-chips, and 3D cultures of the liver to provide clinically relevant insights.

- Work as part of an interdisciplinary team of scientists to iteratively develop quantitative tools to translate PK relationships from preclinical to clinical using modeling and simulation.

- Establish and implement advanced tissue engineering technologies to develop a deeper understanding of DMPK-relevant organ physiology and drug-physiology interactions in vitro.

- Present scientific and technical data to both internal and external collaborators/clients.

- BS, MS, or PhD in Biological Engineering, Bioengineering, Chemical Engineering, Biotechnology, Biology, or related field with 1+ years of relevant lab experience. Appointment level will depend on skill set and years of experience.

- Proven hands-on experience and outstanding laboratory technique (aseptic technique, human/mammalian cell culture, biochemical, bioanalytical assays, etc.); experience working with primary and/or human induced pluripotent stem cell-derived hepatocytes, including isolation, expansion, reprogramming, differentiation, and cryopreservation; knowledge of primary liver cell (hepatocyte and non-parenchymal) isolation is a plus.

- Experience developing and using advanced tissue culture systems including microphysiological systems, tissue chips, organ-on-chips, 3D cultures for ADME assays is a plus.

- Demonstrated scientific experience conducting DMPK-relevant assays and tissue engineering with peer-reviewed publications, presentations and/or patents is a plus.

- Detail-oriented, organized, and scientifically driven with proficient reasoning skills in experimental design, data analysis, and interpretation.

- Excellent written and verbal communication skills; ability to follow complex instructions, multitask, carefully document work in written records.

- Strong data analysis and statistical skills are required (e.g., Prism, MATLAB, R-studio etc.)

- Able to work well under direction as well as independently; self-motivated and able to work as a team in a multidisciplinary, fast-paced, dynamic, and results-oriented environment.