Senior Scientist – Computational Chemistry

Nottingham or Alderley Park /
Computational Chemistry – Computational Chemistry /
Full time
/ On-site
Looking to advance your career in computational chemistry?
As part of Sygnature Discovery’s success and continued expansion, we are looking for innovative and enthusiastic computational chemists to join the organisation at either our Nottingham or Alderley Park locations.
Whether you’ve recently completed your PhD or have several years’ experience under your belt, we’d love to hear from you. Our success has been fuelled by the recruitment of the highest calibre of scientists, and we’re always on the lookout for the best talent to drive our continued growth. 

But why work for us?

    • Computational Chemists at Sygnature Discovery are at the forefront of our scientific research work, driving projects with the latest scientific software and cloud-based technology, solving challenging problems for our clients.
    • You will be part of an expanding group at the forefront of applying new software and techniques to drug discovery projects.
    • You will work on integrated drug discovery projects with some of the most high profile global biotech and pharma.
    • Teamwork and communication are as important as the science we do – how we interact and communicate with our clients is part of our success.
    • We foster a culture of collective responsibility and communal working. If you’re challenged by a problem, your project team, department and the company will support you to find a solution.
    • You will develop drug discovery knowledge by formal training and project experience and have the chance to train and develop expertise using the latest AI/ML software.
    • You will be involved with a range of the new modalities such as protacs, molecular glues, macrocycles and other beyond rule of 5 compounds.
    • You will learn about and apply new and emerging free energy methods to calculate binding energies on projects datasets.
    • We want you to have a long and rewarding career at Sygnature. We can offer a challenging, stimulating and fulfilling role in a sociable team that’s passionate about drug discovery. It’s an extremely motivating and humbling experience to discover a lifesaving drug.

Key requirements:

    • You will have a PhD in computational chemistry or a related discipline.
    • You will have worked on structure-based design projects and be familiar with this approach to optimise ligand binding. 
    • Experience of working on fragment based design projects would also be an advantage.
    • You will have experience of ligand-based design including development of ML or QSAR models. This would include core/fragment replacement work and focussed library design.
    • Familiarity with SAR analysis of project data sets and calculation of ADME/Tox relevant properties.
    • You will have carried our virtual screening, either using protein x-ray structures or a ligand-based method.
    • Protein sequence analysis and homology modelling - experience of multiple sequence alignment and homology modelling across numerous protein classes, including GPCRs, would be an advantage.
    • Familiarity with data pipelining tools and an ability to script in python is preferred.
    • A drug discovery background gained within a pharmaceutical company or a CRO is preferred.
In return you will receive an excellent training and benefits package, including a highly competitive salary which is reviewed annually, a bonus scheme, a well-regarded pension scheme, and private medical insurance. All our benefits are tailored to enhancing your experience at Sygnature as it is important to us that you share in our success.
We also recognise that the environment you work in is a priority, so we have built a collaborative and supportive culture with plenty of opportunities to grow and succeed, tailored to individual and business needs. This includes an excellent set of bespoke training and development courses to accelerate both your scientific and personal career growth.
Since 2011, 40 compounds discovered by Sygnature for customers have entered pre-clinical development. So far, 21 of these have progressed to clinical trials (Phases I, II and III). In 2017, Sygnature Discovery received the prestigious Queen’s Award for Enterprise for International Trade, in 2020 the Medilink Outstanding Achievement Award, and in 2021 the Bionow Company of the Year Award.
For more information, visit
If you’re interested in joining a company that places people at the heart of its business, please apply through the link and include:
1) Your CV
2) Confirmation of your status of eligibility to work in the UK (we can consider sponsoring potential employees with relevant levels of qualifications and experience under a Skilled Worker Visa).
Your application will be submitted through our trusted partners, Lever, but only employees of Sygnature Discovery will review your application and personal data.
We will be interviewing on an ongoing basis, so please submit your application as soon as possible. We look forward to hearing from you.
If you have any questions or need further information, please contact the Careers team at Please do not submit your application to this email address.