Scientist, Biologics
Watertown, MA
Research – Biologics /
Full-time /
On-site
COMPANY INTRODUCTION
Triveni Bio is breaking new ground in the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine. We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) to directly impact skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders. In all the work we do, we adhere to our core values: patient impact, bold and rigorous science, open collaboration, kindness & respect.
SUMMARY
Triveni Bio is in search of an innovative Scientist to join our Biologics team. In this role, you will design and optimize antibodies and proteins to advance Triveni’s therapeutic pipeline. Your work will directly contribute to discovering new treatments for inflammatory diseases by improving library screening, data analysis, and protein engineering processes. On a day-to-day basis, you will design and test protein/antibody libraries using display technologies and analyze sequencing and screening data to identify high potential candidates. This is a unique opportunity to join a dynamic, cross-functional team where your contributions directly impact therapy development.
KEY RESPONSIBILITIES:
- Develop and optimize screening methods to improve functional protein recovery.
- Analyze sequencing and high-throughput screening (HTS) data to guide design.
- Apply computational tools for protein stability prediction and affinity maturation.
- Collaborate with cross-functional teams including biology, bioinformatics, and automation teams to advance therapeutic pipelines.
- Use computational tools (e.g., Rosetta, AlphaFold) to predict protein behavior and guide experiments.
- Other duties as assigned.
QUALIFICATIONS:
- A PhD in Protein Biochemistry, Bioengineering, Computational Biology, or a related field.
- Hands-on experience with display technologies (yeast display required; phage/mammalian a plus) and protein library generation (e.g., error-prone PCR).
- Proficiency in analyzing NGS/HTS data (Python/R, Bioconductor), familiarity with protein modeling software, and ability to integrate computational and experimental workflows.
- Proficiency in Python/R for data analysis and familiarity with protein modeling tools.
Preferred (but not required):
- Knowledge of machine learning/AI applications in protein design.
- Industry experience in therapeutic antibody discovery/optimization.
- Familiarity with antibody sequence-structure relationships.
Triveni Bio, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Official Triveni Bio applications will always be submitted through Lever, our ATS. Any applications that take you to other platforms could be fraudulent. We do not use text or chat applications to conduct interviews or make job offers. Official Triveni Bio correspondence will always be conducted from email addresses ending in @triveni.bio. Please disregard any other communication that does not originate from this domain name. If you receive any suspicious requests or communications, please verify their authenticity before responding.
