Senior Scientist Biotransformation

Novato, CA or Brisbane, CA
Ultragenyx – Pharmacology & Toxicology

Why Join Us?

Ultragenyx is a clinical stage biotechnology company committed to bringing to market novel products for the treatment of rare and ultra-rare diseases with an initial focus on serious debilitating metabolic genetic diseases. Founded in 2010, the company has rapidly built a diverse portfolio of both large and small molecule candidates with the potential to address diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no approved therapies.  
Come join our team during this exciting time of growth and opportunities!
We are headquartered in Novato, CA, 25 miles north of San Francisco, and we also have an office in Brisbane, CA, 10 miles south of San Francisco, and Basel, Switzerland. This position can be located in Novato or Brisbane

Position Summary:

Ultragenyx is seeking a scientist /senior scientist to join the DMPK group. The successful candidate is required to have solid training in biotransformation and apply the knowledge and technical experience to address critical drug metabolism related issues to support drug discovery and development process in multi-disciplinary team setting. 

Responsibilities including, but not limited to:

    •        Design and conduct in vitro/in vivo biotransformation experiments using LC/MSn
    •        Implement LC/MSn methods for metabolic profiling. Interpret MSn data and assign metabolite structures.
    •        Responsible for the operation, maintenance and troubleshooting of LC/MS instrument.
    •        Evaluate in vitro in vivo correlation in pre-clinical species to guide drug design and candidate selection
    •        Design and provide mechanistic interpretation for drug metabolism studies
    •        Represent DMPK in project team
    •        Prepare reports and documents for IND filings 


    •        Ph.D. in Chemistry, Pharmaceutical sciences or related field with 2-5 years of experiences; or MS with more than 5 years relevant industrial experiences
    •        Biotransformation experiences with mass balance and radiochemical studies desirable
    •        Experiences with small molecules drug metabolism studies
    •        Demonstrated leadership experiences with project teams
    •        Ability to design, conduct and report  in vitro and in vivo studies to address ADME related issues
    •        Excellent communication skills

Ultragenyx Pharmaceutical is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status.