Research Scientist - Cancer Biology
San Francisco, CA /
Biology /
/ On-site
About Vevo Therapeutics
Vevo Therapeutics is a biotechnology company using its in vivo drug discovery platform and next generation AI models to uncover better drugs for more patients. The company’s Mosaic platform is the first to make in vivo data generation scalable, with single-cell precision, to capture in vivo context of disease at the first step of drug discovery and to better represent patient diversity in drug response over current in vitro assays. Vevo is using Mosaic to build the world’s largest in vivo atlas of how drugs interact with patient cells and training AI models on its data to find novel targets and drugs undetectable by other technologies.
Your role
At Vevo, we generate a huge amount of data on how drugs interact with cells from many different patients, at a single-cell resolution and in an in vivo context. Using our bioinformatics pipeline, we process this data and perform pathway analysis to develop hypotheses around what targets are involved in treating the diseased cells. A key step after that is to validate those hypotheses and identify the specific targets with high levels of certainty. This role is responsible for extending our platform and technology to perform those validations at scale. This role is part of our experimental team, but is heavily integrated with our bioinformatics team and collaborates with them in refining and testing the hypotheses at scale.
Qualifications
- PhD in experimental biology, cancer biology, genomics, or related discipline
- PhD + 0-6 years of experience in design and implementation of high throughput screening cancer models
- Expert at validating mechanisms of synthetic lethality in cancer especially in RAS/MAPK/PI3K pathways
- Expert at designing and running biochemical assays
- Expert at leveraging high throughput sequencing data to generate hypotheses around drug mechanism of action and tolerance
- Experience in single-cell sequencing methods
- Excellent communication skills and ability to work with technical and non-technical partners from other teams
- You must be legally authorized to work in the U.S and be fully vaccinated against COVID-19, including all eligible booster(s), with the exception of a medical or religious exemption
Key Responsibilities
- Lead target validation efforts using cancer models, xenografts, in vivo studies, knockout/knockdown/overexpression cell line generation, and preclinical tumor growth assays
- Onboard new assays for investigation of MOA discoveries from MOSAIC data using a combination of flow cytometry, western blot, ELISA, and other plate based assays
- Work with computational team for prioritization of targets / oncology indications for deeper investigation
Benefits
- Unlimited Paid Time Off (PTO).
- HMO Kaiser Platinum and PPO Anthem Gold medical as well as vision and dental plans for both the employee and dependents.
- Hybrid remote / onsite workplace (unless presence in office is needed for the role).
