Scientist / Senior Scientist

Utrecht
Netherlands /
Full-Time /
On-site
Xilis, Inc. is an innovation-driven biotech company developing its proprietary MicroOrganoSphere (“MOS”) Technology for functional precision oncology. Xilis’ MOS Technology enables rapid and scalable generation of patient tumor models that retain patient-specific tumor biology and tumor microenvironment, representing one of the most translationally-relevant ex vivo technologies for precision oncology drug discovery and development. Located in Research Triangle Park, Durham, NC, Xilis is building a functional precision medicine platform that incorporates scaled multi-modal profiling of therapeutic activity and AI/ML-enabled analytics to catalyze functional precision medicine drug discovery, development and diagnostics. Collectively, Xilis aims to harness its MOS Platform to enable development of the most effective therapeutics and guide them to the right patients at the right time.

Role
We are looking for a motivated and innovative (Sr.) Scientist to join our growing team to further develop our MicroOrganoSphere (MOS) platform for evaluation of clinically relevant (immuno)therapy. In this role, the Scientist / Sr. Scientist hired will support collaborative projects with Xilis’ strategic partners including academic institutes and potentially biotech and pharma companies focused on leveraging MOS technology in the immuno-oncology space. The selected candidate will work very closely with thought leaders in the fields of cancer immune biology and assay development and will execute critical experiments related to MOS Assay development, participate in detailed analysis, draw conclusions, and formulate next steps / experimental designs. The successful candidate brings exceptional communication skills and will contribute to the Xilis BV’s team-oriented culture. They will present data and lead scientific conversations internally and with partners. The candidate will bring exceptional skills to the laboratory and an ability to independently run large and complex experiments, and will have prior experience in primary cell culture involving immune co-culture assays, immune cell characterization by flow cytometry, and a demonstrated ability to operate lab instrumentation. The candidate will be highly motivated, have a strong work ethic, and have excellent communication skills.
 
The candidate will have the opportunity to fundamentally advance precision cancer care by developing cutting-edge scientific methods into Xilis’ technology portfolio.

Responsibilities

    • Design and run large and complex experiments and develop novel assays
    • Spearhead the most critical assays and experiments necessary to support ongoing assay development efforts
    • Carefully maintain meticulous records of experimental designs, execution details, and results
    • Organize and transparently present experimental results to the cross-functional team
    • Participate in project planning, data analysis, and other scientific activities
    • Support laboratory operations, troubleshooting of issues, SOP development, and maintenance
    • Operate successfully in a rapidly changing, fast-paced, mission-driven environment
    • Share thoughts and ideas on how to improve performance in the lab
    • Participate in meetings with scientific experts from partner organizations. Present data
    • Perform support tasks across the company as needs arise
    • Collaborate and co-develop assays with our Xilis R&D team in the US

Requirements

    • Ph.D. degree in immunology, oncology or a related field
    • 3+ years of postdoctoral laboratory experience in an industrial setting
    • Extensive experience with handling primary tissue samples, primary immune cell cultures and flow cytometry are a must
    • Experience with, cytokine measurements, immunofluorescence, cell viability assays, and confocal microscopy is desirable
    • Experience with assay development is a must
    • A proven track record of independently and successfully running complex experiments
    • Open to engage proactively in scientific discussions
    • A strong enthusiasm for being in the laboratory to personally run experiments
    • Organized and goal-oriented, with project management experience.
    • A strong sense of commitment, integrity and team spirit
    • Experience and interest in a high-growth startup, where communication is key


Xilis was created when its three founders — an engineer, a physician, and a biologist — decided to come together and commercialize their technology to transform cancer care. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. We do not discriminate on the basis of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status. Furthermore, even if your work experience isn't perfectly aligned with what we've described above, if you're excited about what we're building then we want to talk to you!
Xilis offers comprehensive health, vision, dental & retirement plans, and unlimited PTO. We are a remote-friendly team: our headquarters are in Durham, North Carolina, but we have team members across the US (and beyond!).